Gallium, Copper and Metal Fluoride Complexes Designed for Brain Imaging

Grant number: LP150100656 | Funding period: 2016 - 2019

Completed

Abstract

This project aims to develop fundamental synthetic coordination chemistry directed toward the development of new agents for imaging brain perfusion using positron emission tomography. The research will focus on developing new coordination complexes containing positron-emitting isotopes of copper, gallium and fluorine. The goal is incorporate in these radionuclides into small molecules that can be used for the molecular imaging of the brain. This chemistry will have the potential to replace existing technologies that rely on single-photon emission from technetium and the technique of single photon emission computed tomography.

Related publications (8)

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A gallium fluoride-18 complex containing a pentadentate macrocyclic ligand with a dimethylaminostilbene functional group designed for diagnostic imaging of Alzheimer's disease

HJ Koay, MB Haskali, J Van Zuylekom, C Cullinane, CA McLean, JM White, PD Roselt, PS Donnelly

2025-04-29

The molecular pathology of Alzheimer's disease is associated with the presence of aggregates of amyloid-β, a 39-43 amino acid pept..

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Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer's Disease

B Spyrou, IN Hungnes, F Mota, J Bordoloi, PJ Blower, JM White, MT Ma, PS Donnelly

2021-09-06

Alzheimer's disease (AD) is associated with the presence of amyloid plaques in the brain mainly comprised of aggregated forms of a..

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Gallium Fluoride Complexes with Acyclic Bispicolinic Ligands as Potential New Fluorine-18 Labelled Imaging Agents

HJ Koay, MB Haskali, PD Roselt, JM White, PS Donnelly

2020-09-22

The positron-emitting radionuclide, fluorine-18, is used to radiolabel molecules to develop tracers for diagnostic imaging with po..

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Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-β Plaques

A Noor, DJ Hayne, SC Lim, JK Van Zuylekom, C Cullinane, PD Roselt, CA McLean, JM White, PS Donnelly

2020-08-17

Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imagin..

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A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper-64 with High Tumor Uptake and Retention

NA Zia, C Cullinane, JK Van Zuylekom, K Waldeck, LE McInnes, G Buncic, MB Haskali, PD Roselt, RJ Hicks, PS Donnelly

2019-10-14

Molecules containing lysine-ureido-glutamate functional groups bind to the active site of prostate specific membrane antigen, whic..

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A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper‐64 with High Tumor Uptake and Retention

Nicholas A Zia, Carleen Cullinane, Jessica K Van Zuylekom, Kelly Waldeck, Lachlan E McInnes, Gojko Buncic, Mohammad B Haskali, Peter D Roselt, Rodney J Hicks, Paul S Donnelly

2019-10-14

<jats:title>Abstract</jats:title><jats:p>Molecules containing lysine‐ureido‐glutamate functional groups bind to the active site of..

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Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

2019-04-01

The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination re..

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A gallium(III) Schiff base-curcumin complex that binds to amyloid-β plaques

JL Lange, DJ Hayne, P Roselt, CA McLean, JM White, PS Donnelly

2016-09-01

Gallium-68 is a positron-emitting isotope that can be used in positron-emission tomography imaging agents. Alzheimer's disease is ..

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